Duchenne Muscular Dystrophy

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

Also Known As:

Muscular Dystrophy, Becker; Becker Muscular Dystrophy; Muscular Dystrophy, Duchenne; Becker's Muscular Dystrophy; Cardiomyopathy, Dilated, 3B; Cardiomyopathy, Dilated, X-Linked; Childhood Muscular Dystrophy, Pseudohypertrophic; Childhood Pseudohypertrophic Muscular Dystrophy; Duchenne and Becker Muscular Dystrophy; Duchenne-Becker Muscular Dystrophy; Duchenne-Type Progressive Muscular Dystrophy; Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type; Muscular Dystrophy, Becker Type; Muscular Dystrophy, Childhood, Pseudohypertrophic; Muscular Dystrophy, Duchenne Type; Muscular Dystrophy, Duchenne and Becker Types; Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type; Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type; Muscular Dystrophy, Pseudohypertrophic, Childhood; Progressive Muscular Dystrophy, Duchenne Type; Pseudohypertrophic Childhood Muscular Dystrophy; Pseudohypertrophic Muscular Dystrophy, Childhood; Duchenne Becker Muscular Dystrophy; Duchenne Type Progressive Muscular Dystrophy; Muscular Dystrophy, Becker's; Muscular Dystrophy, Duchenne-Becker; Pseudohypertrophic Muscular Dystrophy; Muscular Dystrophy, Pseudohypertrophic

Musculoskeletal Diseases: 751
- Muscular Diseases: 10368
  - Atrophic Muscular Disorders: 327
    - Muscular Dystrophies: 5839
      - Duchenne Muscular Dystrophy: 6596
Nervous System Diseases: 14737
- Neuromuscular Diseases: 2048
  - Muscular Diseases: 10368
    - Atrophic Muscular Disorders: 327
      - Muscular Dystrophies: 5839
        Duchenne Muscular Dystrophy: 6596
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Inborn Genetic Diseases: 12342
  - Muscular Dystrophies: 5839
    - Duchenne Muscular Dystrophy: 6596
  - X-Linked Genetic Diseases: 42
    - Duchenne Muscular Dystrophy: 6596

CINRG Duchenne Natural History Investigators Selected Research

CINRG Duchenne Natural History Investigators Research Topics

Disease

Drug/Important Bio-Agent (IBA)